igfbp 2 levels Search Results


serum igfbp2 levels  (Johns Hopkins HealthCare)
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Circulating IGF axis proteins levels
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Circulating IGF axis proteins levels
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Circulating IGF axis proteins levels
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Image Search Results


Circulating IGF axis proteins levels

Journal: BMC Medicine

Article Title: Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival

doi: 10.1186/s12916-020-01734-3

Figure Lengend Snippet: Circulating IGF axis proteins levels

Article Snippet: Serum IGFBP2 levels, as well as IGF1/2 levels, were measured in two independent PAH cohorts, the Johns Hopkins Pulmonary Hypertension program (JHPH, N = 127), NHLBI PAHBiobank (PAHB, N = 203), and a healthy control cohort ( N = 128).

Techniques: Control

Box and whisker plot of serum IGFBP2 levels in subgroups of APAH ( N = 81) and IPAH ( N = 46) in JHPH cohort ( a ) versus healthy control ( N = 128). Boxes represent the interquartile range (IQR 5–95%) and horizontal lines are the median. Outliers are indicated with solid dots. b The subgroups of APAH ( N = 98), IPAH ( N = 85), and FAPH ( N = 20) in the PAHB cohort in the same style

Journal: BMC Medicine

Article Title: Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival

doi: 10.1186/s12916-020-01734-3

Figure Lengend Snippet: Box and whisker plot of serum IGFBP2 levels in subgroups of APAH ( N = 81) and IPAH ( N = 46) in JHPH cohort ( a ) versus healthy control ( N = 128). Boxes represent the interquartile range (IQR 5–95%) and horizontal lines are the median. Outliers are indicated with solid dots. b The subgroups of APAH ( N = 98), IPAH ( N = 85), and FAPH ( N = 20) in the PAHB cohort in the same style

Article Snippet: Serum IGFBP2 levels, as well as IGF1/2 levels, were measured in two independent PAH cohorts, the Johns Hopkins Pulmonary Hypertension program (JHPH, N = 127), NHLBI PAHBiobank (PAHB, N = 203), and a healthy control cohort ( N = 128).

Techniques: Whisker Assay, Control

Comparison of receiver operating curves (ROC) for IGF1, IGF2, and IGFBP2as predictors of pulmonary arterial hypertension for 127 subjects from the JHPH cohort and 128 healthy control subjects. The AUC for IGFBP2 is 0.76, 95% confidence interval [CI] 0.698–0.808, p < 0.0001; AUC for IGF1 is 0.52, 95% confidence interval [CI] 0.455–0.583, p = 0.61; and AUC for IGF2 is 0.50, 95% confidence interval [CI] 0.438–0.566, p = 0.96

Journal: BMC Medicine

Article Title: Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival

doi: 10.1186/s12916-020-01734-3

Figure Lengend Snippet: Comparison of receiver operating curves (ROC) for IGF1, IGF2, and IGFBP2as predictors of pulmonary arterial hypertension for 127 subjects from the JHPH cohort and 128 healthy control subjects. The AUC for IGFBP2 is 0.76, 95% confidence interval [CI] 0.698–0.808, p < 0.0001; AUC for IGF1 is 0.52, 95% confidence interval [CI] 0.455–0.583, p = 0.61; and AUC for IGF2 is 0.50, 95% confidence interval [CI] 0.438–0.566, p = 0.96

Article Snippet: Serum IGFBP2 levels, as well as IGF1/2 levels, were measured in two independent PAH cohorts, the Johns Hopkins Pulmonary Hypertension program (JHPH, N = 127), NHLBI PAHBiobank (PAHB, N = 203), and a healthy control cohort ( N = 128).

Techniques: Comparison, Control

Associations (unadjusted) between IGFBP2 and clinical variables

Journal: BMC Medicine

Article Title: Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival

doi: 10.1186/s12916-020-01734-3

Figure Lengend Snippet: Associations (unadjusted) between IGFBP2 and clinical variables

Article Snippet: Serum IGFBP2 levels, as well as IGF1/2 levels, were measured in two independent PAH cohorts, the Johns Hopkins Pulmonary Hypertension program (JHPH, N = 127), NHLBI PAHBiobank (PAHB, N = 203), and a healthy control cohort ( N = 128).

Techniques:

Associations (adjusted for age and sex) between IGFBP2 and clinical variables

Journal: BMC Medicine

Article Title: Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival

doi: 10.1186/s12916-020-01734-3

Figure Lengend Snippet: Associations (adjusted for age and sex) between IGFBP2 and clinical variables

Article Snippet: Serum IGFBP2 levels, as well as IGF1/2 levels, were measured in two independent PAH cohorts, the Johns Hopkins Pulmonary Hypertension program (JHPH, N = 127), NHLBI PAHBiobank (PAHB, N = 203), and a healthy control cohort ( N = 128).

Techniques:

Kaplan-Meier survival curve for IGFBP2 in the JHPH cohort. The curves represent survival analysis of JHPH cohort dichotomized by median serum IGFBP2 ( n = 125, p = 0.0001) concentration

Journal: BMC Medicine

Article Title: Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival

doi: 10.1186/s12916-020-01734-3

Figure Lengend Snippet: Kaplan-Meier survival curve for IGFBP2 in the JHPH cohort. The curves represent survival analysis of JHPH cohort dichotomized by median serum IGFBP2 ( n = 125, p = 0.0001) concentration

Article Snippet: Serum IGFBP2 levels, as well as IGF1/2 levels, were measured in two independent PAH cohorts, the Johns Hopkins Pulmonary Hypertension program (JHPH, N = 127), NHLBI PAHBiobank (PAHB, N = 203), and a healthy control cohort ( N = 128).

Techniques: Concentration Assay

Kaplan-Meier survival curve for IGFBP2 in the PAHB cohort. The curves represent survival analysis of PAH cohort dichotomized by median serum IGFBP2 ( n = 200, p < 0.0001) concentration

Journal: BMC Medicine

Article Title: Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival

doi: 10.1186/s12916-020-01734-3

Figure Lengend Snippet: Kaplan-Meier survival curve for IGFBP2 in the PAHB cohort. The curves represent survival analysis of PAH cohort dichotomized by median serum IGFBP2 ( n = 200, p < 0.0001) concentration

Article Snippet: Serum IGFBP2 levels, as well as IGF1/2 levels, were measured in two independent PAH cohorts, the Johns Hopkins Pulmonary Hypertension program (JHPH, N = 127), NHLBI PAHBiobank (PAHB, N = 203), and a healthy control cohort ( N = 128).

Techniques: Concentration Assay

IGFBP2 protein levels in the lung tissues measured by western blot using IGFBP2 specific antibody or actinin level as a loading control ( a ). C1–C4 are control donor lung samples, and P1–P4 are lung samples from PAH patients. Box and whisker plot of IGFBP2 protein levels in lung samples from PAH patients versus from controls ( b ). Boxes represent the interquartile range (IQR 5–95%) and horizontal lines are the median. The IGFBP2 protein level in each sample (bands in a ) was quantified using ImageJ software

Journal: BMC Medicine

Article Title: Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival

doi: 10.1186/s12916-020-01734-3

Figure Lengend Snippet: IGFBP2 protein levels in the lung tissues measured by western blot using IGFBP2 specific antibody or actinin level as a loading control ( a ). C1–C4 are control donor lung samples, and P1–P4 are lung samples from PAH patients. Box and whisker plot of IGFBP2 protein levels in lung samples from PAH patients versus from controls ( b ). Boxes represent the interquartile range (IQR 5–95%) and horizontal lines are the median. The IGFBP2 protein level in each sample (bands in a ) was quantified using ImageJ software

Article Snippet: Serum IGFBP2 levels, as well as IGF1/2 levels, were measured in two independent PAH cohorts, the Johns Hopkins Pulmonary Hypertension program (JHPH, N = 127), NHLBI PAHBiobank (PAHB, N = 203), and a healthy control cohort ( N = 128).

Techniques: Western Blot, Control, Whisker Assay, Software

Box and whisker plot of IGFBP2 mRNA levels in PAEC ( N = 10) versus that in PASMC ( N = 13). Boxes represent the interquartile range (IQR 5–95%) and horizontal lines are the median

Journal: BMC Medicine

Article Title: Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival

doi: 10.1186/s12916-020-01734-3

Figure Lengend Snippet: Box and whisker plot of IGFBP2 mRNA levels in PAEC ( N = 10) versus that in PASMC ( N = 13). Boxes represent the interquartile range (IQR 5–95%) and horizontal lines are the median

Article Snippet: Serum IGFBP2 levels, as well as IGF1/2 levels, were measured in two independent PAH cohorts, the Johns Hopkins Pulmonary Hypertension program (JHPH, N = 127), NHLBI PAHBiobank (PAHB, N = 203), and a healthy control cohort ( N = 128).

Techniques: Whisker Assay

Box and whisker plot of IGFBP2 protein levels in conditional medias from PAEC ( N = 14) versus that in PASMC ( N = 22); IGFBP2 level was normalized by cultured cell protein concentration. Boxes represent the interquartile range (IQR 5–95%) and horizontal lines are the median

Journal: BMC Medicine

Article Title: Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival

doi: 10.1186/s12916-020-01734-3

Figure Lengend Snippet: Box and whisker plot of IGFBP2 protein levels in conditional medias from PAEC ( N = 14) versus that in PASMC ( N = 22); IGFBP2 level was normalized by cultured cell protein concentration. Boxes represent the interquartile range (IQR 5–95%) and horizontal lines are the median

Article Snippet: Serum IGFBP2 levels, as well as IGF1/2 levels, were measured in two independent PAH cohorts, the Johns Hopkins Pulmonary Hypertension program (JHPH, N = 127), NHLBI PAHBiobank (PAHB, N = 203), and a healthy control cohort ( N = 128).

Techniques: Whisker Assay, Cell Culture, Protein Concentration